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Single molecule dynamics in nanoporous systems: single dye molecules act as nanoscopic reporters diffusing through the pores of the mesoporous silica revealing details of the interaction and the structure of these novel materials. Mechanistical studies of translation, rotation, adsorption and spectral diffusion of single molecules in mesoporous silica structures and other nanoporous systems

Mackowiak S., Bräuchle C.  
Study of Single Molecule Dynamics in Mesoporous Systems, Glasses and Living Cells  
in "Nonequilibrium Statistical Physics of Small Systems: Fluctuation relations and beyond"  
Eds.: Klages R., Just W., Jarzynski C.  
Wiley-VCH Weinheim (2013), p. 393.

Rühle B., Davies M., Bein T., Bräuchle C.
Fluorescence Microscopy Studies of Porous Silica Materials
Z. Naturforsch. (68b) (2013), 423.

Feil F., Naumov S., Michaelis J., Valiullin R., Enke D., Kärger J., Bräuchle C. Single-particle and ensemble diffusivities - Test of ergodicity  
Angewandte Chemie  124(5)  (2012), 1178.  
Angewandte Chemie Internat. Edition  51(5)  (2012), 1152.
Cover picture for Angewandte Chemie Internat. Edition (January 2012, 51(5)

Feil F., Cauda V., Bein T.,*, Bräuchle C.*  
Direct Visualization of Dye and Oligonucleotide Diffusion in Silica Filaments with Collinear Mesopores  
Nano Lett.  12(3)  (2012), 1354.

Rühle B., Davies M., Lebold T., Bräuchle C.*, Bein T.*  
Highly Oriented Mesoporous Silica Channels Synthesized in Microgrooves and Visualized with Single Molecule Diffusion  
ACS Nano  6(3)  (2012), 1948.

Lebold T., Michaelis J., Bräuchle C.*
The complexity of mesoporous silica nanomaterials unraveled by single molecule microscopy
Phys. Chem. Chem. Phys. 13 (2011), 5017.

Jung C.,Schwaderer P., Dethlefsen M., Köhn R., Michaelis J., Bräuchle C.
Visualization of the Self Assembly of Silica Nanochannels reveals growth mechanism
Nature Nanotechnology 6, (2011) 87.
Figure from this publication: cover picture for Nature Nanotechnology, Issue 2 (February 2011 Volume 6 No 2)

Michaelis J., Bräuchle C.
Reporters in the Nanoworld – Diffusion of single molecules in mesoporous materials
Chem. Soc. Rev. 39(12), (2010), 4731.

Bräuchle C.
 Exploring Nanostructured Systems with Single Molecule Probes: From Nanoporous Materials to Living Cells
in "Single Molecule Spectroscopy in Chemistry, Physics and Biology" Nobel Symposium
Springer Series in Chemical Physics, Vol. 96, Part 10
Eds: Gräslund A., Rigler R., Widengren J.
Verlag: Springer Berlin Heidelberg (2010), S. 537-551

Jung C., Bräuchle C.
Visualizing Single-Molecule Diffusion in Nanochannel Systems
in "Single Particle Tracking and Single Molecule Energy Transfer"
Eds.: C. Bräuchle, D.C. Lamb, J. Michaelis
Wiley VCH Weinheim (2009), S. 309.

Feil F., Jung C., Kirstein J., Michaelis J., Li C., Nolde F., Müllen K., Bräuchle C.*
Diffusional and orientational dynamics of various single terrylene diimide conjugates in mesoporous materials
Microporous and Mesoporous Materials 125 (2009), 70.

Lebold T., Mühlstein L.A., Blechinger J., Riederer M., Amenitsch H., Köhn R., Peneva K., Müllen K., Michaelis J., Bräuchle C., Bein T.
Tuning Single-Molecule Dynamics in Functionalized Mesoporous Silica
Chem. Eur. J. 15 (2009), 1661.

Jung C., Kirstein J., Platschek B., Bein T., Budde M., Frank I., Müllen K., Michaelis J., Bräuchle C.*
Diffusion of Oriented Single Molecules with Switchable Mobility in Networks of Long Unidimensional Nanochannels
J. Am. Chem. Soc. 130(5), (2008), 1638.

Jung C., Hellriegel C., Platschek B., Wöhrle D., Bein T., Michaelis J., Bräuchle C.*
Simultaneous measurement of orientational and spectral dynamics of single molecules in nanostructured host-guest materials
JACS, 129(17), (2007), 5570.

Jung C., Hellriegel C., Michaelis J., Bräuchle C.*
Single Molecule Traffic in Mesoporous Materials: Translational, Orientational and Spectral Dynamics
Adv. Mater. 19 (2007) 956.

Zürner A., Kirstein J., Döblinger M., Bräuchle C.*, Bein T.*
Visualizing single molecule diffusion in mesoporous materials
Nature, 450, (2007) 705.

Kirstein J., Platschek B., Jung C., Brown R., Bein T., Bräuchle C.*
Exploration of Nanostructured Channel Systems by Single Molecule Probes
Nature Mat. 6, (2007) 303.

Universität München
Department Chemie
Physikalische Chemie I
Butenandtstr. 11
D-81377 München
Phone: +49-89-2180-77547
Mail: Prof. C. Braeuchle
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June 2018

New publication: Invasiveness of cells changes their interaction behaviour with the glycocalyx Advanced Biosystems, (2018), DOI: 10.1002/adbi.201800083 more information... 

New publication: Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ, ChemBioChem 18, (2017), 1716. more information... 

New publication: Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter, BBA - Molecular Cell Research, 1864(12) (2017), 2330. more information... 

New publication: Spektromikroskopie für biologische Fragestellungen in der Physikalischen Chemie, p. 85, Beitrag im Buch “Unendliche Weiten: Kreuz und quer durchs Chemie-Universum”, Eds.: T.K. Lindhorst, H-J.Quadbeck-Seeger, Gesellschaft Deutscher Chemiker Wiley VCH Verlag GmbH (2017). more information... 

New publication: New insights into the intracellular distribution pattern of cationic amphiphilic drugs, Scientific Reports (2017), Article number 44277. more information... 

New publication: Azido pentoses: A New Tool to Efficiently Label Mycobacterium tuberculosis Clinical Isolates, ChemBioChem 18 (2017), 1172. more information... 

New publication: The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood−Tissue Border ACS Nano, 11(2), (2017), 1498. more information... 

New publication: The Glycocalyx Regulates the Uptake of Nanoparticles by Human Endothelial Cells In Vitro, Nanomedicine 12(3) (2017), 207.  more information... 

New publication: Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases, Oncotarget 7(31) (2016), 50461. more information... 

New publication: En route from artificial to natural: Evaluation of inhibitors of mannose-specific adhesion of E. coli under flow , Biochimica et Biophysica Acta 1860 (2016), 2031. more information... 

New publication: Cell Membrane Penetration and Mitochondrial Targeting by Platinum-Decorated Ceria Nanoparticles, Nanoscale 8 (2016), 13352. more information... 

New publication: Dendronized Mesoporous Silica Nanoparticles Provide an Internal Endosomal Escape Mechanism for Successful Cytosolic Drug Release, Microporous and Mesoporous Materials 227 (2016), 242. more information... 

New publication: Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release, Nanoscale (2016), 8101. more information... 


New publication: Highly efficient siRNA delivery from core–shell mesoporous silica nanoparticles with multifunctional polymer caps, Nanoscale 8 (2016), 4007. more information... 


New publication: Artificial Formation and Tuning of Glycoprotein Networks on Live Cell Membranes: A Single-Molecule Tracking Study, ChemPhysChem 17(6) (2016), 829. more information... 


New publication: Switching first contact: photocontrol of E. coli adhesion to human cells, Chem. Comm. 52 (2016), 1254. more information... 

Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ